cpn-3
F28H1.2 | CalPoNin 3
cpn-3 encodes a calponin homolog, most closely related to its paralog CPN-4 in C. elegans; CPN-3 is more similar to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25 than to calponin per se.
Graphics for cpn-3
3'UTR Zoom
Locus
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3'UTR mapped for cpn-3
If available, we display here the 3'UTRs sequences we obtained by our analysis (in FASTA format). Putative canonical PAS sites, if found, are highlighted in yellow.1
ID: 779 -
Tier: 1 -
Name: cpn-3 -
Cosmid: F28H1.2 -
WBGeneID: WBGene00000779 -
Length: 147 -
PAS: AATAAA
Cluster Coverage (%): 90970 reads (100.00%)
(See this 3'UTR in GBrowse!) (See this Gene in GBrowse!)
id | Name | Chr | Strand | Start | End | Length | PAS | Coverage |
---|---|---|---|---|---|---|---|---|
779 | cpn-3 | I | + | 3988554 | 3988700 | 147nt | AATAAA (-21nt) | 90970 reads |
This 3'UTR isoform has been detected in the following tissues:
UTRome v31 | Intestine2 | Pharynx2 | Body Muscle2 | Arcade cells2 | GABA neurons2 | NMDA neurons2 | Hypodermis2 | Seam cells2 |
---|---|---|---|---|---|---|---|---|
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2Blazie et al., 2016 - Alternative polyadenylation directs tissue specific miRNA targeting in Caenorhabditis elegans somatic tissues. - under review (mixed stages & tissue-specific datasets)
>|3'UTR|147nt|I:3988554..3988700|PAS:AATAAA
aaaccaacccauccaacucaagaauuccaaaaauggccaagcccuugcaauguuucacccgauaccuucucauauccuaa uaauaugauuuucuucuuuucuucuuuuuuuguuguacaaaacaaaauaaaguuguuuggucaaca
Updated miRanda Targets for cpn-3 (Murari et al., submitted)
cpn-3 transcript has been predicted to be targeted by the following miRNAs:ID | miRNA | Target Gene | Score | Energy | % Binding (Target) | % Binding (miRNA) |
---|---|---|---|---|---|---|
11203 | cel-miR-54-5p | cpn-3 | 157 | -18.28 | 91.67 | 91.67 | 54253 | cel-miR-355-5p | cpn-3 | 140 | -6.60 | 100.00 | 100.00 |
Predicted or Experimental Interactors for cpn-3 (WormBase)
cpn-3 has been predicted to interact with the following genes (data from WS200):- csq-1 Lee I et al. (2008)
- lea-1 Lee I et al. (2008)
The lea-1 gene encodes a protein that is predicted to be hydrophilic and heat-resistant, and that might participate in anhydrobiosis. - lec-5 Lee I et al. (2008)
none available - pat-10 Lee I et al. (2008)
pat-10 encodes body wall muscle troponin C, the calcium-binding component of the troponin complex of actin thin filaments; PAT-10 is essential for muscle contraction and thus for completion of embryonic morphogenesis and elongation; by homology, PAT-10 likely functions to regulate body wall muscle contraction in response to changes in intracellular calcium; PAT-10 is expressed in body wall muscle but is also detected in vulval and anal muscles; expression in body wall muscle begins during early embryonic morphogenesis, concurrent with expression of other body wall muscle structural components. - qdpr-1 Lee I et al. (2008)
The T03F6.1 gene encodes an ortholog of the human gene QUINOID DIHYDROPTERIDINE REDUCTASE (QDPR; DHPR), which when mutated leads to phenylketonuria II (OMIM:261630). - rme-2 Lee I et al. (2008)
rme-2 encodes a member of the low-density lipoprotein (LDL) receptor superfamily; RME-2 functions as the C. elegans yolk receptor whose activity is required for yolk uptake during oogenesis; RME-2 is expressed in developing oocytes where it localizes at or near the cell surface. - unc-27 Lee I et al. (2008)
unc-27 encodes a troponin I isoform; unc-27 is required for coordinated motility and normal muscle morphology; structural analyses indicate that unc-27 is required for proper sarcomeric organization; unc-27/troponin I interacts with the body wall and pharynx types of troponin C; expression studies show that unc-27 is expressed in body wall, vulval and anal muscles.
More on cpn-3
Related Papers
There are no recent papers related to cpn-3.Related cpn Genes
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The APAome Project is currently funded by the School of Life Sciences at Arizona State University