unc-108
F53F10.4 | UNCoordinated 108
unc-108 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; unc-108 function is required in neurons for normal locomotion; unc-108 also functions in the removal of apoptotic cells, specifically it functions in engulfing cells for the recruitment and fusion of the lysosome to the phagosome; unc-108 is expressed in neurons and in engulfing cells.
Graphics for unc-108
3'UTR Zoom
Locus
see this gene in GBrowse
Operon Information
This gene is part of the operon CEOP1116 (I:3828133..3824949)CEOP1116 contains 2 genes in the following order:
Blumenthal et al., Nature 417, 851-854
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3'UTR mapped for unc-108
If available, we display here the 3'UTRs sequences we obtained by our analysis (in FASTA format). Putative canonical PAS sites, if found, are highlighted in yellow.1
ID: 5759 -
Tier: 1 -
Name: unc-108 -
Cosmid: F53F10.4 -
WBGeneID: WBGene00006833 -
Length: 482 -
PAS: aatgaa
Cluster Coverage (%): 31019 reads (100.00%)
(See this 3'UTR in GBrowse!) (See this Gene in GBrowse!)
id | Name | Chr | Strand | Start | End | Length | PAS | Coverage |
---|---|---|---|---|---|---|---|---|
5759 | unc-108 | I | + | 3826043 | 3826524 | 482nt | aatgaa (-26nt) | 31019 reads |
This 3'UTR isoform has been detected in the following tissues:
UTRome v31 | Intestine2 | Pharynx2 | Body Muscle2 | Arcade cells2 | GABA neurons2 | NMDA neurons2 | Hypodermis2 | Seam cells2 |
---|---|---|---|---|---|---|---|---|
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2Blazie et al., 2016 - Alternative polyadenylation directs tissue specific miRNA targeting in Caenorhabditis elegans somatic tissues. - under review (mixed stages & tissue-specific datasets)
>|3'UTR|482nt|I:3826043..3826524|PAS:aatgaa
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Updated miRanda Targets for unc-108 (Murari et al., submitted)
unc-108 transcript has been predicted to be targeted by the following miRNAs:ID | miRNA | Target Gene | Score | Energy | % Binding (Target) | % Binding (miRNA) |
---|---|---|---|---|---|---|
52212 | cel-miR-265 | unc-108 | 165 | -30.64 | 75.00 | 93.75 | 8032 | cel-miR-46-5p | unc-108 | 160 | -14.41 | 73.68 | 73.68 | 8391 | cel-miR-47-5p | unc-108 | 160 | -14.42 | 73.68 | 73.68 | 44501 | cel-miR-249-3p | unc-108 | 160 | -17.10 | 63.16 | 84.21 | 69117 | cel-miR-797-5p | unc-108 | 158 | -11.60 | 73.68 | 78.95 | 2443 | cel-miR-2-3p | unc-108 | 157 | -13.57 | 65.00 | 75.00 | 138056 | cel-miR-8192-3p | unc-108 | 155 | -12.99 | 66.67 | 77.78 | 96513 | cel-miR-4805-3p | unc-108 | 155 | -6.54 | 78.57 | 85.71 | 14466 | cel-miR-61-3p | unc-108 | 155 | -11.66 | 72.22 | 72.22 | 125953 | cel-miR-5549-3p | unc-108 | 154 | -16.12 | 70.00 | 75.00 | 35564 | cel-miR-234-5p | unc-108 | 154 | -11.10 | 72.73 | 72.73 | 146579 | cel-miR-8206-3p | unc-108 | 153 | -13.29 | 72.22 | 77.78 | 123328 | cel-miR-5547-5p | unc-108 | 152 | -9.38 | 76.19 | 76.19 | 129830 | cel-miR-5551-5p | unc-108 | 152 | -12.98 | 73.33 | 80.00 | 133365 | cel-miR-356b-5p | unc-108 | 149 | -15.92 | 60.00 | 70.00 | 16517 | cel-miR-67-5p | unc-108 | 149 | -12.16 | 50.00 | 80.00 | 46206 | cel-miR-253-5p | unc-108 | 148 | -7.76 | 84.62 | 84.62 | 41699 | cel-miR-247-5p | unc-108 | 148 | -8.45 | 73.33 | 73.33 | 80453 | cel-miR-1828 | unc-108 | 147 | -14.58 | 65.00 | 70.00 | 109475 | cel-miR-4925 | unc-108 | 147 | -8.17 | 90.00 | 90.00 | 41700 | cel-miR-247-5p | unc-108 | 146 | -9.10 | 88.89 | 100.00 | 7688 | cel-miR-45-3p | unc-108 | 146 | -11.47 | 88.89 | 100.00 | 71611 | cel-miR-800-5p | unc-108 | 146 | -7.08 | 63.16 | 73.68 | 7092 | cel-miR-44-3p | unc-108 | 146 | -11.47 | 88.89 | 100.00 | 151313 | cel-miR-2217b-1-5p | unc-108 | 145 | -18.66 | 100.00 | 100.00 | 138057 | cel-miR-8192-3p | unc-108 | 145 | -11.10 | 100.00 | 100.00 | 107450 | cel-miR-4923a | unc-108 | 145 | -10.16 | 100.00 | 100.00 | 41701 | cel-miR-247-5p | unc-108 | 145 | -7.91 | 100.00 | 100.00 | 40643 | cel-miR-246-5p | unc-108 | 143 | -11.21 | 64.29 | 78.57 | 150966 | cel-miR-8210-3p | unc-108 | 143 | -13.82 | 61.11 | 66.67 | 57439 | cel-miR-358-3p | unc-108 | 142 | -11.05 | 88.89 | 88.89 | 107451 | cel-miR-4923a | unc-108 | 141 | -9.16 | 87.50 | 100.00 | 43794 | cel-miR-247-3p | unc-108 | 141 | -14.06 | 87.50 | 100.00 | 41702 | cel-miR-247-5p | unc-108 | 141 | -9.54 | 90.00 | 90.00 | 139593 | cel-miR-8196a-3p | unc-108 | 141 | -8.24 | 71.43 | 78.57 | 45016 | cel-miR-250-3p | unc-108 | 140 | -10.05 | 100.00 | 100.00 | 6257 | cel-miR-43-3p | unc-108 | 140 | -9.18 | 100.00 | 100.00 |
Predicted or Experimental Interactors for unc-108 (WormBase)
unc-108 has been predicted to interact with the following genes (data from WS200):- cct-4 Lee I et al. (2008)
- gdi-1 Lee I et al. (2008)
gdi-1 encodes a member of the Rab GDP dissociation inhibitor (GDI) family with high similarity to Drosophila Gdi; expressed around the pharyngeal, vulval, and tail regions. - nhr-49 Lee I et al. (2008)
none available - rab-6.2 Lee I et al. (2008)
rab-6.2 encodes a small, monomeric Rab GTPase that is most closely related to the Drosophila and mammalian Rab6 GTPases; by homology, RAB-6.2 is predicted to function in the regulation of intracellular membrane trafficking; RNAi experiments indicate that rab-6.2 is required redundantly with rab-6.1 for normal embryonic development and reproduction. - tag-210 Lee I et al. (2008)
none available
More on unc-108
Related Papers
Systematic functional analysis of the Ras GTPase family unveils a conserved network required for anterograde protein trafficking.
Proteomics 2017-01-01
Proteomics 2017-01-01
Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation.
Proc. Natl. Acad. Sci. U.S.A. 2010-10-19
Proc. Natl. Acad. Sci. U.S.A. 2010-10-19
Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2.
J. Cell Biol. 2009-09-21
J. Cell Biol. 2009-09-21
The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans.
J. Cell Biol. 2008-01-28
J. Cell Biol. 2008-01-28
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The APAome Project is currently funded by the School of Life Sciences at Arizona State University